LeHavreV1, France, Analysis, bibRecord, 001522

[Multicenter study of sodium alginate in the treatment of regurgitation in infants].

Identifieur interne : 001522 ( France/Analysis ); précédent : 001521; suivant : 001523

[Multicenter study of sodium alginate in the treatment of regurgitation in infants].

Auteurs : B. Le Luyer [France] ; J F Mougenot ; L. Mashako ; P. Chapoy ; J P Olives ; A. Morali ; B. Chevallier ; J L Ginies ; C. Dupont ; M. Dagorne

Source :

Annales de pediatrie [ 0066-2097 ] ; 1992.

RBID : pubmed:1485782

Descripteurs français

Wicri :
- geographic : France.

English descriptors

KwdEn :
- Alginates (administration & dosage), Alginates (adverse effects), Alginates (therapeutic use), Aluminum Hydroxide (administration & dosage), Aluminum Hydroxide (adverse effects), Aluminum Hydroxide (therapeutic use), Bicarbonates (administration & dosage), Bicarbonates (adverse effects), Bicarbonates (therapeutic use), Child, Preschool, Drug Combinations, Endoscopy, Gastrointestinal, Female, France (epidemiology), Gastric Acidity Determination, Gastroesophageal Reflux (diagnosis), Gastroesophageal Reflux (drug therapy), Gastroesophageal Reflux (epidemiology), Humans, Infant, Infant, Newborn, Male, Silicic Acid (administration & dosage), Silicic Acid (adverse effects), Silicic Acid (therapeutic use), Sodium Bicarbonate.
MESH :
- chemical , administration & dosage : Alginates, Aluminum Hydroxide, Bicarbonates, Silicic Acid.
- chemical , adverse effects : Alginates, Aluminum Hydroxide, Bicarbonates, Silicic Acid.
- chemical , therapeutic use : Alginates, Aluminum Hydroxide, Bicarbonates, Silicic Acid.
- geographic , epidemiology : France.
- diagnosis : Gastroesophageal Reflux.
- drug therapy : Gastroesophageal Reflux.
- epidemiology : Gastroesophageal Reflux.
- Child, Preschool, Drug Combinations, Endoscopy, Gastrointestinal, Female, Gastric Acidity Determination, Humans, Infant, Infant, Newborn, Male, Sodium Bicarbonate.

Abstract

An open multicenter study was performed to assess the efficacy and safety of alginic acid in two different dosages in 76 pediatric patients with gastroesophageal reflux confirmed by pH monitoring. Among the 69 patients in whom endoscopy was carried out before treatment, 18 had erythematous esophagitis and 5 had erosive esophagitis. Irrespective of the dosage used, the frequency of regurgitation and vomiting decreased significantly (p < 0.00001 and p = 0.01, respectively). Clinical and biochemical tolerance were outstanding and no adverse effects were recorded. On the basis of these data, the recommended dosage is 1 to 2 ml/kg/day in divided doses after meals.

PubMed: 1485782

Affiliations:

Links to Exploration step

pubmed:1485782

Le document en format XML

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<author><name sortKey="Mougenot, J F" sort="Mougenot, J F" uniqKey="Mougenot J" first="J F" last="Mougenot">J F Mougenot</name>
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<author><name sortKey="Mashako, L" sort="Mashako, L" uniqKey="Mashako L" first="L" last="Mashako">L. Mashako</name>
</author>
<author><name sortKey="Chapoy, P" sort="Chapoy, P" uniqKey="Chapoy P" first="P" last="Chapoy">P. Chapoy</name>
</author>
<author><name sortKey="Olives, J P" sort="Olives, J P" uniqKey="Olives J" first="J P" last="Olives">J P Olives</name>
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<author><name sortKey="Morali, A" sort="Morali, A" uniqKey="Morali A" first="A" last="Morali">A. Morali</name>
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<author><name sortKey="Chevallier, B" sort="Chevallier, B" uniqKey="Chevallier B" first="B" last="Chevallier">B. Chevallier</name>
</author>
<author><name sortKey="Ginies, J L" sort="Ginies, J L" uniqKey="Ginies J" first="J L" last="Ginies">J L Ginies</name>
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<author><name sortKey="Dupont, C" sort="Dupont, C" uniqKey="Dupont C" first="C" last="Dupont">C. Dupont</name>
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<author><name sortKey="Dagorne, M" sort="Dagorne, M" uniqKey="Dagorne M" first="M" last="Dagorne">M. Dagorne</name>
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<author><name sortKey="Olives, J P" sort="Olives, J P" uniqKey="Olives J" first="J P" last="Olives">J P Olives</name>
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<author><name sortKey="Morali, A" sort="Morali, A" uniqKey="Morali A" first="A" last="Morali">A. Morali</name>
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<author><name sortKey="Chevallier, B" sort="Chevallier, B" uniqKey="Chevallier B" first="B" last="Chevallier">B. Chevallier</name>
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<author><name sortKey="Ginies, J L" sort="Ginies, J L" uniqKey="Ginies J" first="J L" last="Ginies">J L Ginies</name>
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<author><name sortKey="Dupont, C" sort="Dupont, C" uniqKey="Dupont C" first="C" last="Dupont">C. Dupont</name>
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<author><name sortKey="Dagorne, M" sort="Dagorne, M" uniqKey="Dagorne M" first="M" last="Dagorne">M. Dagorne</name>
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<term>Aluminum Hydroxide (adverse effects)</term>
<term>Aluminum Hydroxide (therapeutic use)</term>
<term>Bicarbonates (administration & dosage)</term>
<term>Bicarbonates (adverse effects)</term>
<term>Bicarbonates (therapeutic use)</term>
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<term>Drug Combinations</term>
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<term>Female</term>
<term>France (epidemiology)</term>
<term>Gastric Acidity Determination</term>
<term>Gastroesophageal Reflux (diagnosis)</term>
<term>Gastroesophageal Reflux (drug therapy)</term>
<term>Gastroesophageal Reflux (epidemiology)</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Male</term>
<term>Silicic Acid (administration & dosage)</term>
<term>Silicic Acid (adverse effects)</term>
<term>Silicic Acid (therapeutic use)</term>
<term>Sodium Bicarbonate</term>
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<term>Gastric Acidity Determination</term>
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<front><div type="abstract" xml:lang="en">An open multicenter study was performed to assess the efficacy and safety of alginic acid in two different dosages in 76 pediatric patients with gastroesophageal reflux confirmed by pH monitoring. Among the 69 patients in whom endoscopy was carried out before treatment, 18 had erythematous esophagitis and 5 had erosive esophagitis. Irrespective of the dosage used, the frequency of regurgitation and vomiting decreased significantly (p < 0.00001 and p = 0.01, respectively). Clinical and biochemical tolerance were outstanding and no adverse effects were recorded. On the basis of these data, the recommended dosage is 1 to 2 ml/kg/day in divided doses after meals.</div>
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<name sortKey="Dupont, C" sort="Dupont, C" uniqKey="Dupont C" first="C" last="Dupont">C. Dupont</name>
<name sortKey="Ginies, J L" sort="Ginies, J L" uniqKey="Ginies J" first="J L" last="Ginies">J L Ginies</name>
<name sortKey="Mashako, L" sort="Mashako, L" uniqKey="Mashako L" first="L" last="Mashako">L. Mashako</name>
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[Multicenter study of sodium alginate in the treatment of regurgitation in infants].

[Multicenter study of sodium alginate in the treatment of regurgitation in infants].

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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